| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurology and Psychiatry (Drs. Huff and Boiler), and the Department of Epidemiology (Mr. Auerbach) and Human Genetics Program (Dr. Chakravarti), Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Using a family history questionnaire, we investigated the occurrence of dementia among relatives of patients with a clinical diagnosis of Alzheimer's disease (AD) and among the relatives of age-matched control subjects. Cumulative lifetime risk of developing AD-type dementia was greater among relatives of AD probands and was consistent with an autosomal dominant genetic mode of transmission. Although the lifetime risk of AD-type dementia was similar among relatives of early-onset and late-onset AD probands, relatives of early-onset probands tended to have an earlier onset of dementia than did relatives of late-onset AD probands. This result raises the possibility that age at onset of dementia in AD may be genetically determined.
Address correspondence and reprint requests to Dr. Huff, Alzheimer's Disease Research Center, Suite 400, Iroquois Building, 3600 Forbes Avenue, Pittsburgh, PA 15213.
Supported by NIH grants AG00232, AG03705, AG05133, MH30915, GM33771, and HD00774.
Received July 31, 1987. Accepted for publication in final form September 30, 1987.
This article has been cited by other articles:
|
|
 |
|
  J. M. Silverman, G. Ciresi, C. J. Smith, D. B. Marin, and M. Schnaider-Beeri Variability of Familial Risk of Alzheimer Disease Across the Late Life Span Arch Gen Psychiatry, May 1, 2005; 62(5): 565 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Levy, E. D. Louis, H. Mejia-Santana, L. Cote, H. Andrews, J. Harris, C. Waters, B. Ford, S. Frucht, S. Fahn, et al. Lack of Familial Aggregation of Parkinson Disease and Alzheimer Disease Arch Neurol, July 1, 2004; 61(7): 1033 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Devi, J. Williamson, F. Massoud, K. Anderson, Y. Stern, D. P. Devanand, and R. Mayeux A Comparison of Family History of Psychiatric Disorders Among Patients With Early- and Late-Onset Alzheimer's Disease J Neuropsychiatry Clin Neurosci, February 1, 2004; 16(1): 57 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Heun, A. Papassotiropoulos, F. Jessen, W. Maier, and J. C. S. Breitner A Family Study of Alzheimer Disease and Early- and Late-Onset Depression in Elderly Patients Arch Gen Psychiatry, February 1, 2001; 58(2): 190 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Devi, R. Ottman, M.-X. Tang, K. Marder, Y. Stern, and R. Mayeux Familial Aggregation of Alzheimer Disease Among Whites, African Americans, and Caribbean Hispanics in Northern Manhattan Arch Neurol, January 1, 2000; 57(1): 72 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Green and A. I. Levey Event-Related Potential Changes in Groups at Increased Risk for Alzheimer Disease Arch Neurol, November 1, 1999; 56(11): 1398 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Marder, M.-X. Tang, B. Alfaro, H. Mejia, L. Cote, E. Louis, Y. Stern, and R. Mayeux Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia Neurology, March 1, 1999; 52(4): 719 - 719. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Zubenko, H. B. Hughes III, and J. S. Stiffler Neurobiological correlates of a putative risk allele for Alzheimer's disease on chromosome 12q Neurology, March 1, 1999; 52(4): 725 - 725. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. S. Zubenko, E. Winwood, B. Jacobs, I. Teply, J. S. Stiffler, H. B. Hughes III, F. J. Huff, T. Sunderland, and A. J. Martinez Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years Am J Psychiatry, January 1, 1999; 156(1): 50 - 57. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
