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From the Department of Neurology (Drs. Jagust, Friedland, and Koss), School of Medicine, University of California, Davis; Veterans Administration Medical Center (Drs. Jagust, Friedland, Koss, and Ober), Martinez, CA; Donner Laboratory (Drs. Jagust, Friedland, and Budinger), University of California, Berkeley; Veterans Administration Medical Center (Dr. Ober), Livermore, CA; and Laboratory of Neurosciences (Drs. Friedland and Koss), National Institute on Aging, NIH, Betbeada, MD.
Measurement of cerebral glucose metabolism in six patients with Alzheimer's disease using positron emission tomography demonstrated that hypometabolism remained relatively more severe in parietal cortex than in frontal cortex over time. Lateral metabolic asymmetries were preserved in less severely involved brain regions, but were less stable in parietal cortex.
Address correspondence and reprint requests to Dr. Jagust, Department of Neurology (127), Veterans Administration Medical Center, 150 Muir Road, Martinez, CA 94553.
Supported by NIH grant AG05890 from the National Institute on Aging, by the Medical Research Service of the United States Veterans Administration, and by the Director, Office of Energy Research, Office of Health and Environmental Research of the United States Department of Energy under contract DE-AC03-76SF00098.
Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.
Received June 16, 1987. Accepted for publication in final form October 23, 1987.
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