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NEUROLOGY 1988;38:928
© 1988 American Academy of Neurology

Progressive myoclonus epilepsy treated with zonisamide

Thomas R. Henry, MD, Ilo E. Leppik, MD, Robert J. Gumnit, MD and Margaret Jacobs, AB

From the Minnesota Comprehensive Epilepsy Program, Minneapolis, MN.

Two patients with progressive myoclonus epilepsy of the Unverricht-Lundborg type and with intractable seizures in spite of standard anticonvulsant regimens were treated with zonisamide. After zonisamide therapy was initiated, both had a marked decrease in seizure frequency and significant improvement of functioning. Serum zonisamide concentrations were 43 and 27 µg/ml, respectively, with doses of 8.8 and 10.5 mg/kg/d. Both patients also continue to receive valproic acid and a benzodiazepine.

Address correspondence and reprint requests to Dr. Henry, Reed Neurological Research Center, 710 Westwood Plaza, Room 1250, University of California at Los Angeles, Los Angeles, CA 90024.

Supported in part by NIH Grant #l-P50-NS-16308.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, May 1986.

Received July 14, 1986. Accepted for publication in final form October 16, 1987.




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