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NEUROLOGY 1988;38:1018
© 1988 American Academy of Neurology

A variant of the anti-Purkinje cell antibody in a patient with paraneoplastic cerebellar degeneration

N. E. Anderson, MB, ChB, C. Budde-Steffen, MD, R. G. Wiley, MD, PhD, L. Thunnan, MD, M. K. Rosenblum, MD, S. E. Nadeau, MD and J. B. Posner, MD

From the Departments of Neurology (Drs. Anderson, Budde-Steffen, and Posner), and Pathology (Neuropathology) (Dr. Rosenblum), Memorial Sloan-Kettering Cancer Center, and Cornell University Medical College, New York, NY; Departments of Neurology (Dr. Wiley), and Pathology (Dr. Thurman), Vanderbilt University and Veterans Administration Medical Center, Nashville, TN; and the Department of Neurology (Dr. Nadeau), Veterans Administration Medical Center, Jackson, MS.

An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic staining, did not react with PCD antigens in Purkinje cell Western blots, and the antigen had a different species distribution. Unlike the antinuclear antibody found in patients with PCD and small-cell lung carcinoma, the antigen was restricted to the cytoplasm of Purkinje cells. If autoantibodies are important in the pathogenesis of PCD, this case illustrates that they can recognize different antigenic epitopes in the nervous system, but cause similar clinicopathologic syndromes.

Address correspondence and reprint requests to Dr. Posner, Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Received January 27, 1987. Accepted for publication in final form November 17,1987.

Dr. Anderson was supported by the New Zealand Neurological Foundation and by funds granted by the Norman and Rosita Winston Foundation and the Michael and Ethel L. Cohen Foundation.




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