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Treatment response in malignant optic glioma of adulthood

From the Department of Neurology (Dr. Albers), Stanford University Medical Center, Stanford, CA; the Neuro-Ophthalmology Unit (Dr. Hoyt), University of California, San Francisco, CA; the Veterans' Administration Medical Center (Dr. Forno), Palo Alto, CA; and the Department of Radiology (Dr. Shratter), Stanford University Medical Center, Stanford, CA.

Two adults with malignant optic gliomas displayed dramatic tumor shrinkage and prolonged survival after radiation therapy alone in one case and combined radiation and chemotherapy in the other. Although malignant optic gliomas have been reported to be radiation resistant, marked treatment response may occur and aggressive treatment protocols should be considered.

Address correspondence to Dr. Albers, Department of Neurology, Stanford University Medical Center, Stanford, CA 94305. Address reprint requests to Dr. Hoyt, 876 Moffit Hospital, University of California, San Francisco, San Francisco, CA 94143.

Received September 15,1987. Accepted for publication in final form November 17,1987.

Supported in part by the Veterans' Administration Medical Research Program.