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NEUROLOGY 1988;38:1133
© 1988 American Academy of Neurology

Preclinical Creutzfeldt-Jakob disease discovered at autopsy in a human growth hormone recipient

M. I. New, MD, P. Brown, MD, J. W. Temeck, MD, C. Owens, AB, E. T. Hedley-Whyte, MD and E. P. Richardson, MD

From the Division of Pediatric Endocrinology (Drs. New and Temeck, and Ms. Owens), Department of Pediatrics, The New York Hospital-Cornell University Medical Center, New York, NY; the Laboratory of Central Nervous System Studies (Dr. Brown), NINCDS, National Institutes of Health, Bethesda, MD; and the Division of Neuropathology (Drs. Hedley-Whyte and Richardson), Department of Pathology, Massachusetts General Hospital, Boston, MA.

An adolescent girl with idiopathic hypothalamic dysfunction and hypopituitarism was treated with human growth hormone between 1969 and 1979, dying of parainfluenza pneumonia 2 months after her last hormone treatment. Although she had no signs of progressive neurologic disease, reexamination of autopsy material revealed a focus of spongiform change and astrogliosis in the corpus striatum. Thus, this growth hormone recipient, who died of intercurrent infection, was unexpectedly found to be in an early, preclinical phase of Creutzfeldt-Jakob disease.

Address correspondence and reprint requests to Dr. Brown, Building 36, Room 5B21, NINCDS, NIH, Bethesda, MD 20892.

Received September 2, 1987. Accepted for publication in final form November 25, 1987.




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