| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Medical Neurology Branch and Neuroimaging Section, National Institute of Neurological and Communicative Disorders and Stroke, Division of Intramural Research, National Institutes of Health, Bethesda, MD.
We analyzed local cerebral metabolic rates of glucose (LCMRglu) in 20 regions from 22 patients with complex partial seizures, who were taking neither phenytoin nor phenobarbital and who had normal CTs. Results were compared with data from 19 normal controls. Ten patients had left temporal, eight right temporal, and four bitemporal or generalized EEG discharges. There were no significant differences between patient and control values in any of 20 regions of interest. LCMRglu was depressed at the site of the epileptic focus: L/R ratio was 0.85 ± 0.12 (p < 0.003 compared with control), 0.92 ± 0.08 (p < 0.05), and 0.84 ± 0.1 (p < 0.001), respectively, in mesial, superior, and inferior temporal regions for patients with left temporal foci; 1.7 ± 0.96 (p < 0.04), 1.1 ± 0.1 (NS), and 1.15 ± 0.04 (p < 0.001) for patients with right temporal foci. Patients with left temporal EEG foci had significantly lower values than patients with right temporal foci in left superior frontal and thalamic as well as left temporal regions, while patients with right-sided EEG foci had depressed LCMRglu (compared with patients with left temporal EEG foci) restricted to right mesial temporal lobe. The patients with left temporal foci tended to have longer seizure histories (22.7 ± 5.4 versus 11 ± 5.6 years; p < 0.001). There was an inverse correlation between length of seizure history and mean LCMRglu (r = 0.38; 0.1 > p > 0.05). Our study suggests that LCMRglu is not depressed in regions beyond the epileptic focus when patients are not taking drugs known to decrease cerebral glucose metabolism.
Address correspondence and reprint requests to Dr. Theodore, NIH, Building 10, Room 5N–248, Bethesda, MD 20892.
Received July 10, 1987. Accepted for publication in final form December 22, 1987.
This article has been cited by other articles:
|
|
 |
|
  E. Asano, C. Juhasz, A. Shah, S. Sood, and H. T. Chugani Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery Brain, April 1, 2009; 132(4): 1038 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Scheid, T. Lincke, R. Voltz, D. Y. von Cramon, and O. Sabri Serial 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography and Magnetic Resonance Imaging of Paraneoplastic Limbic Encephalitis Arch Neurol, November 1, 2004; 61(11): 1785 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.D. Gaillard, L. Kopylev, S. Weinstein, J. Conry, P.L. Pearl, M.V. Spanaki, S. Fazilat, S. Fazilat, L.G. Venzina, E. Dubovsky, et al. Low incidence of abnormal 18FDG-PET in children with new-onset partial epilepsy: A prospective study Neurology, March 12, 2002; 58(5): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Bednarczyk Functional Imaging for the Monitoring of Clinical Outcomes of Pharmacotherapy Journal of Pharmacy Practice, August 1, 2001; 14(4): 298 - 307. [Abstract] [PDF]
|
|
|
|
|
|
S. Lamusuo, L. Jutila, A. Ylinen, R. Kalviainen, E. Mervaala, M. Haaparanta, S. Jaaskelainen, K. Partanen, M. Vapalahti, and J. Rinne [18F]FDG-PET Reveals Temporal Hypometabolism in Patients With Temporal Lobe Epilepsy Even When Quantitative MRI and Histopathological Analysis Show Only Mild Hippocampal Damage Arch Neurol, June 1, 2001; 58(6): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dupont, F. Semah, S. Clemenceau, C. Adam, M. Baulac, and Y. Samson Accurate Prediction of Postoperative Outcome in Mesial Temporal Lobe Epilepsy: A Study Using Positron Emission Tomography With 18Fluorodeoxyglucose Arch Neurol, September 1, 2000; 57(9): 1331 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Regis, F. Semah, R. N. Bryan, O. Levrier, M. Rey, Y. Samson, and J.-C. Peragut Early and Delayed MR and PET Changes after Selective Temporomesial Radiosurgery in Mesial Temporal Lobe Epilepsy AJNR Am. J. Neuroradiol., February 1, 1999; 20(2): 213 - 216. [Abstract] [Full Text]
|
|
|
|
|
|
W. H. Theodore, S. Bhatia, J. Hatta, S. Fazilat, C. DeCarli, S. Y. Bookheimer, and W. D. Gaillard Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures Neurology, January 1, 1999; 52(1): 132 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Savic and J. Engel Jr Sex differences in patients with mesial temporal lobe epilepsy J. Neurol. Neurosurg. Psychiatry, December 1, 1998; 65(6): 910 - 912. [Abstract] [Full Text]
|
|
|
|
|
|
I. Savic, L. Altshuler, L. Baxter, and J. Engel Jr Pattern of Interictal Hypometabolism in PET Scans With Fludeoxyglucose F 18 Reflects Prior Seizure Types in Patients With Mesial Temporal Lobe Seizures Arch Neurol, February 1, 1997; 54(2): 129 - 136. [Abstract] [PDF]
|
|
|
|
|
|
D. B. Leiderman, P. Albert, M. Balish, E. Bromfield, and W. H. Theodore The Dynamics of Metabolic Change Following Seizures as Measured by Positron Emission Tomography With Fludeoxyglucose F 18 Arch Neurol, September 1, 1994; 51(9): 932 - 936. [Abstract] [PDF]
|
|
|
|
|
|
J. I. Victoroff, D. F. Benson, S. T. Grafton, J. Engel Jr, and J. C. Mazziotta Depression in Complex Partial Seizures Electroencephalography and Cerebral Metabolic Correlates Arch Neurol, February 1, 1994; 51(2): 155 - 163. [Abstract] [PDF]
|
|
|
|
|
|
T. R. Henry, J. C. Mazziotta, and J. Engel Jr Interictal Metabolic Anatomy of Mesial Temporal Lobe Epilepsy Arch Neurol, June 1, 1993; 50(6): 582 - 589. [Abstract] [PDF]
|
|
|
|
|
|
E. B. Bromfield, L. Altshuler, D. B. Leiderman, M. Balish, T. A. Ketter, O. Devinsky, R. M. Post, and W. H. Theodore Cerebral Metabolism and Depression in Patients With Complex Partial Seizures Arch Neurol, June 1, 1992; 49(6): 617 - 623. [Abstract] [PDF]
|
|
|
|
|
|
R. W. Homan, R. G. Paulman, M. D. Devous Sr, P. Walker, L. W. Jennings, and F. J. Bonte Cognitive Function and Regional Cerebral Blood Flow in Partial Seizures Arch Neurol, September 1, 1989; 46(9): 964 - 970. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
