Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marttila, R. J.
Right arrow Articles by Rinne, U. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marttila, R. J.
Right arrow Articles by Rinne, U. K.
NEUROLOGY 1988;38:1217
© 1988 American Academy of Neurology

Parkinson's disease in a nationwide twin cohort

R. J. Marttila, MD, J. Kaprio, MD, M. Koskenvuo, MD and U. K. Rinne, MD

Department of Neurology, University of Turku (Drs. Marttila and Rinne)
Department of Public Health Science, University of Helsinki, Finland (Drs. Kaprio and Koskenvuo).

The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finnish Sickness Insurance Register. We ascertained altogether 42 cases of Parkinson's disease occurring in 41 twin pairs, including 18 monozygotic pairs, 14 dizygotic pairs, and nine pairs of undetermined zygosity. Only one dizygotic pair was concordant for Parkinson's disease; all other pairs were discordant. In 1981, the expected number of cases among the Twin Cohort, calculated according to the age- and sex-specific prevalence rates of Parkinson's disease in Finland, was 33. At the same time, the observed number of patients alive was 35. This study, further substantiating the low concordance for Parkinson's disease in monozygotic as well as in dizygotic twins and indicating that the prevalence of Parkinson's disease in twins compares with the prevalence in the general population, suggests that Parkinson's disease is an acquired disease not caused by a hereditary process.

Address correspondence and reprint requests to Dr. Marttila, Department of Neurology, University of Turku, SF-20520 Turku, Finland.

Received September 30, 1987. Accepted for publication in final form December 31, 1987.




This article has been cited by other articles:


Home page
 NeurologyHome page
K. Wirdefeldt, M. Gatz, M. Schalling, and N. L. Pedersen
No evidence for heritability of Parkinson disease in Swedish twins
Neurology, July 27, 2004; 63(2): 305 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. R. Uhl and R. W. Grow
The Burden of Complex Genetics in Brain Disorders
Arch Gen Psychiatry, March 1, 2004; 61(3): 223 - 229.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
A. Siderowf and M. Stern
Update on Parkinson Disease
Ann Intern Med, April 15, 2003; 138(8): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T Foltynie, S Sawcer, C Brayne, and R A Barker
The genetic basis of Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, October 1, 2002; 73(4): 363 - 370.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. A. Schwarzschild, J.-F. Chen, and A. Ascherio
Caffeinated clues and the promise of adenosine A2A antagonists in PD
Neurology, April 23, 2002; 58(8): 1154 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. A. Racette, M. Rundle, J. C. Wang, A. Goate, N. L. Saccone, M. Farrer, S. Lincoln, J. Hussey, S. Smemo, J. Lin, et al.
A multi-incident, Old-Order Amish family with PD
Neurology, February 26, 2002; 58(4): 568 - 574.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. H. V. Schapira
Neuroprotection and dopamine agonists
Neurology, February 1, 2002; 58(90001): S9 - 18.
[Abstract] [Full Text]

Home page
 NeurologyHome page
A. Samii, K. Markopoulou, Z. K. Wszolek, V. Sossi, T. Dobko, E. Mak, D. B. Calne, and A. J. Stoessl
PET studies of parkinsonism associated with mutation in the {alpha}-synuclein gene
Neurology, December 1, 1999; 53(9): 2097 - 2097.
[Abstract] [Full Text]

Home page
 NeurologyHome page
P. Vieregge, J. Hagenah, I. Heberlein, C. Klein, and H.-P. Ludin
Parkinson's disease in twins: A follow-up study
Neurology, August 1, 1999; 53(3): 566 - 566.
[Abstract] [Full Text]

Home page
 JAMAHome page
C. M. Tanner, R. Ottman, S. M. Goldman, J. Ellenberg, P. Chan, R. Mayeux, and J. W. Langston
Parkinson Disease in Twins: An Etiologic Study
JAMA, January 27, 1999; 281(4): 341 - 346.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. L. Cummings
Understanding Parkinson Disease
JAMA, January 27, 1999; 281(4): 376 - 378.
[Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
K. Furuya, K. Sano, H. Segawa, K. Ide, and H. Yoneyama
Symptomatic tonsillar ectopia
J. Neurol. Neurosurg. Psychiatry, February 1, 1998; 64(2): 221 - 226.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
I. Heberlein, H.-P. Ludin, J. Scholz, and P. Vieregge
Personality, depression, and premorbid lifestyle in twin pairs discordant for Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, February 1, 1998; 64(2): 262 - 266.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by AAN Enterprises, Inc.