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'On-off' phenomenon in Parkinson's disease

Relationship between dopa and other large neutral amino acids in plasma

Department of Pharmacology, Valla Hospital, University of Linköping, Sweden (Drs. Eriksson and Carlsson)
Laboratory of Oral Biology, University of Göteborg-, Valla Hospital, University of Linköping, Sweden (Dr. Linde)
Department of Geriatrics and Long Term Care Medicine, Valla Hospital, University of Linköping, Sweden (Dr. Granérus).

Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain.

Address correspondence and reprint requests to Dr. Eriksson, Department of Pharmacology, University of Göteborg, PO Box 33031, S-400 33 Göteborg, Sweden.

Supported by Merck Sharp & Dohme (Sweden) AB, The Swedish Medical Research Council, and the Göteborg Medical Society.

Received September 25, 1985. Accepted for publication in final form December 29, 1987.

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