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Comparison of [¹⁴C]-deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rat C₆ glioma

Departments of Neurology, Pathology, and Pharmacology, University of Michigan, Ann Arbor, MI.

A rat C₆ glioma tumor model has demonstrated that C₆ tumor cells express a high density of peripheral benzodiazepine (BDZ) receptors. We report a poor correlation between the density of peripheral BDZ receptors and tumor metabolism using [¹⁴C]-deoxyglucose in this C₆ glioma model. We also compared the abilities of in vivo and in vitro BDZ receptor binding and tumor metabolism to measure the tumor area. All imaging methods were capable of estimating both the gross and total tumor area and had similar specificities and sensitivities. Because of a high signal-to-noise ratio, in vivo peripheral BDZ receptor binding may be a useful method for determining tumor size in human tumors expressing the receptor using PET.

Address correspondence and reprint requests to Dr. Young, Neuroscience Laboratory Building, 1103 East Huron, Ann Arbor, MI 48104–1687.

Supported by USPHS grant NS 15655.

Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.

Received September 9, 1987. Accepted for publication in final form December 22, 1987.