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Reactivity with the peripheral myelin glycoprotein P_o in serum from patients with monoclonal IgM gammopathy and polyneuropathy

Department of Neurobiology, University of Heidelberg, Heidelberg, Federal Republic of Germany (Drs. Bollensen and Schachner)
Department of Neurology, Centre Hospitalier Univeraitaire Vaudois, Lausanne, Switzerland (Dr. Steck).

The major glycoprotein P_o from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P_o, while serum that did not react with MAG also did not recognize P_o. Furthermore, the neural adhesion molecules L1, N-CAM, and J1 were also recognized by the serum that reacted with MAG, while the L3 carbohydrate-carrying cell adhesion molecule AMOG was not recognized. These observations indicate a restricted specificity in carbohydrate reactivity of IgM paraproteins and implicate yet another and, for the first time, peripheral myelin-specific glycoprotein in the pathogenesis of demyelinating neuropathy.

Address correspondence and reprint requests to Dr. Bollensen, Department of Neurology, University of Göttingen, Robert-Koch-Strasse 40, D 3400 Göttingen, Federal Republic of Germany.

Supported by Deutsche Forschungsgemeinschaft (SFB 317 and fellowship to Dr. Bollensen).

Received August 24, 1987. Accepted for publication in final form December 8, 1987.

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