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NEUROLOGY 1988;38:1281
© 1988 American Academy of Neurology

CSF {alpha}-MSH in dementia of the Alzheimer type

I. Rainero, MD, C. May, MD, J. A. Kaye, MD, R. P. Friedland, MD and S. I. Rapoport, MD

Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Betheada, MD.

We measured CSF {alpha}-melanocyte stimulating hormone-like immunoreactivity ({alpha}-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean {alpha}-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls. However, when the DAT patients were analyzed according to age at onset of dementia or presence of extrapyramidal signs, {alpha}-MSH-LI concentrations remained significantly lower than in controls only in DAT patients with late onset of dementia (>65 years of age). No correlation was found between {alpha}-MSH levels and degree of mental impairment. A significant negative correlation was found between CSF concentrations of {alpha}-MSH and homovanillic acid in the group of all DAT patients (p < 0.001). These results suggest that hypothalamic neurons which produce pro-opiomelanocortin-related peptides may be involved in Alzheimer's disease.

Address correspondence and reprint requests to Dr. May, Laboratory of Neurosciences, NLA, National Institutes of Health, Building 10, Room 12S207, 9000 Rockville Pike, Bethesda, MD 20892.

Received July 9, 1987. Accepted for publication in final form December 10, 1987.




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