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Department of Neurology, Neurological Institute, Kyushu University, Japan (Drs. Itoyama, Minato, Kira, and Goto)
Clinical Laboratory, Kyushu University Hospital, Fukuoka, Japan (Drs. Sato and Okochi)
Department of Virology and Parasitology, Yamaguchi University, School of Medicine, Ube, Japan (Dr. Yamamoto).
We found unstimulated (spontaneous) peripheral blood lymphocyte (PBL) proliferation significantly increased in 14 patients with human T-lymphotropic virus (HTLV)-I-associated myelopathy (HAM) compared with findings in HTLV-I seropositive non-HAM carriers (N = 8) or HTLV-I seronegative controls (N = 16). The proliferative response to phytohemagglutinin, concanavalin A, or pokeweed mitogen was decreased in the HAM patients. Cell clusters were frequent in cultures of unstimulated PBL from the HAM patients, but much less common in the controls or carriers. This spontaneous PBL proliferation was depressed when adherent-cell populations were depleted from the cultures. IL-2 activity increased in the supernatant of 3-day cultured cells from HAM patients, but not in cultured cells from the controls. Since IL-2 receptor positive cells increased in HAM, this spontaneous PBL proliferation is probably a response to IL-2 through the expression of IL-2 receptors.
Address correspondence and reprint requests to Dr. Itoyama, Department of Neurology, Neurological Institute, Kyushu University 60, Fukuoka 812, Japan.
Supported by grants from the Neuroimmunological Disease Research Committee and from the Slow Virus Infection Research Committee, the Ministry of Health and Welfare of Japan.
Received September 9, 1987. Accepted for publication in final form January 14, 1988.
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