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Effect of food on the serum concentration profile of entericcoated valproic acid

Clinical Pharmacokinetics Laboratory, College of Medicine, University of Illinois at Chicago, Chicago, IL (Dr. Fischer)
Department of Pharmacy Practice, College of Medicine, University of Illinois at Chicago, Chicago, IL (Dr. Paloucek, Dorociak, and Spunt)
College of Pharmacy, and the Department of Neurology, College of Medicine, University of Illinois at Chicago, Chicago, IL (Dr. Barr).

We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.

Address correspondence and reprint requests to Dr. Barr, Department of Neurology (m/c 796), University of Illinois at Chicago, 912 South Wood Street, Room 855, Chicago, IL 60612.

Received August 4, 1987. Accepted for publication in final form December 29, 1987.

This article has been cited by other articles:

				S. Dutta, R. C Reed, and R. F O'Dea Comparative Absorption Profiles of Divalproex Sodium Delayed-Release Versus Extended-Release Tablets--Clinical Implications Ann. Pharmacother., April 1, 2006; 40(4): 619 - 625. [Abstract] [Full Text] [PDF]