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Is ischemia implicated in chronic multifocal demyelinating neuropathy?

Peripheral Nerve Laboratory, Department of Medicine, The Neuroscience Center, University of Otago, Dunedin (Drs. Nukada and Pollock)
Department of Medicine, Wellington Clinical School, Wellington, New Zealand. (Dr. Haas)

We describe a patient with chronic multifocal demyelinating neuropathy associated with persistent conduction block. Multifascicular lesions in sural nerve included a complete loss of myelinated fibers, demyelination, remyelination, onion bulb formation, and axonal attenuation. On the basis of these morphometric results we hypothesize that nerve ischemia may be involved in the pathogenesis of chronic multifocal demyelinating neuropathy

Address correspondence and reprint requests to Dr. Nukada, Department of Medicine, University of Otago Medical School, PO Box 913, Dunedin, New Zealand.

Supported in part by grants from the New Zealand Neurological Foundation and the National Heart Foundation of New Zealand.

Received January 6, 1988. Accepted for publication in final form July 25, 1988.