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Hypoxic neuropathy Does hypoxia play a role in diabetic neuropathy?

The 1988 Robert Wartenberg Lecture

Peripheral Neuropathy Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, MN.

In this report I review: (1) the blood supply and endoneurial microenvironment of nerve; (2) the class, type, and spatial distribution of nerve fiber degeneration as a function of number, site, and class of vessels occluded; (3) the putative mechanisms of nerve hypoxia; and (4) the role of hypoxia in diabetic polyneuropathy.

Supported in part by Peripheral Neuropathy Clinical Center Grant NS-14304 from NINCDS, a Center Grant from the Muscular Dystrophy Association, Mayo Foundation, Borchard Foundation, and Upton Funds.

Address correspondence and reprint requests to Dr. Dyck, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Received July 13, 1988. Accepted for publication in final form July 13, 1988.

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