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NEUROLOGY 1989;39:1297
© 1989 American Academy of Neurology

Seizures after liver transplantation

A clinicopathologic study

Conrado J. Estol, MD, Oscar Lopez, MD, Richard P. Brenner, MD and A. Julio Martinez, MD

Department of Neurology, Presbyterian-University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA. (Drs. Estol, Lopez, and Brenner)
Department of Psychiatry, Presbyterian-University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA. (Dr. Brenner)
Department of Pathology, Neuropathology Division, Presbyterian-University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA. (Dr. Martinez)

We reviewed the clinical and neuropathologic findings in 21 patients who had seizures after orthotopic liver transplants. Tonic-clonic seizures were the most common seizure type. Six patients developed status epilepticus. In 9 patients, seizures occurred within 1 week following transplantation. We found CNS lesions that were probably responsible for the occurrence of seizures in most patients; some had more than 1 finding. Neuropathologic examination revealed ischemic or hemorrhagic strokes in 18 patients, central pontine myelinolysis in 5, and CNS infections in 5. Multiple metabolic abnormalities were a contributing factor to the onset of seizures in some patients.

Address correspondence and reprint requests to Dr. Estol, Tufts University, Neurology Department, New England Medical Center Hospitals, 750 Washington Street, Boston, MA 02111

Presented in part at the forty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received February 13, 1989. Accepted for publication in final form April 27, 1989.




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M. B. Lewis and P. D. Howdle
Neurologic complications of liver transplantation in adults
Neurology, November 11, 2003; 61(9): 1174 - 1178.
[Abstract] [Full Text] [PDF]


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