| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Irene Walter Johnson Rehabilitation Institute (Speech Pathology), Washington University School of Medicine, St. Louis, MO. (Ms. Bushmann and Ms. Leeker)
Department of Neurology and Neurological Surgery (Neurology), Washington University School of Medicine, St. Louis, MO. (Drs. Dobmeyer and Perlmutter)
Mallinckrodt Institute of Radiology (Radiation Sciences), Washington University School of Medicine, St. Louis, MO. (Dr. Perlmutter)
We investigated swallowing abnormalities in patients with Parkinson's disease, the relationship between these abnormalities and general parkinsonian signs, as well as the response to therapy. Twenty patients and 13 controls were evaluated with clinical rating scales and modified barium swallows before and after oral levodopa (in combination with carbidopa). Fifteen patients, but only 1 control, had abnormal swallows (
2 = 11.722, df = l, p < 0.001). Abnormalities included disturbances of oral and pharyngeal phases of swallowing. Patients without dysphagia frequently had abnormal swallows, including silent aspiration. Seven patients had improved swallowing after levodopa, whereas 1 worsened. Improvement in general parkinsonian signs was not a reliable indicator of improved swallowing.
Address correspondence and reprint requests to Dr. Perlmutter, Division of Radiation Sciences, #1 Barnes Hospital Plaza, St. Louis, MO 63110.
Supported by Teacher Investigator Development Award NS00929 (to J.S.P.) and by the Greater St. Louis Chapter of the American Parkinson's Disease Association.
Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.
Received January 17, 1989. Accepted for publication in final form April 11, 1989.
This article has been cited by other articles:
|
|
 |
|
  C. W. Olanow, M. B. Stern, and K. Sethi The scientific and clinical basis for the treatment of Parkinson disease (2009) Neurology, May 26, 2009; 72(21_Supplement_4): S1 - S136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. PANDYA, C. S. KUBU, and M. L. GIROUX Parkinson disease: Not just a movement disorder Cleveland Clinic Journal of Medicine, December 1, 2008; 75(12): 856 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. DiSario Future Considerations in Aspiration Pneumonia in the Critically Ill Patient: What Is Not Known, Areas for Future Research, and Experimental Methods JPEN J Parenter Enteral Nutr, November 1, 2002; 26(6_suppl): S75 - S79. [Abstract] [PDF]
|
|
|
|
|
|
C. W. Olanow, R. L. Watts, and W. C. Koller An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment Neurology, June 12, 2001; 56(suppl_5): S1 - S88. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Muller, G. K. Wenning, M. Verny, A. McKee, K. R. Chaudhuri, K. Jellinger, W. Poewe, and I. Litvan Progression of Dysarthria and Dysphagia in Postmortem-Confirmed Parkinsonian Disorders Arch Neurol, February 1, 2001; 58(2): 259 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G D Perkin and I Murray-Lyon Neurology and the gastrointestinal system J. Neurol. Neurosurg. Psychiatry, September 1, 1998; 65(3): 291 - 300. [Full Text]
|
|
|
|
|
|
P C Hunter, J Crameri, S Austin, M C Woodward, and A J Hughes Response of parkinsonian swallowing dysfunction to dopaminergic stimulation J. Neurol. Neurosurg. Psychiatry, November 1, 1997; 63(5): 579 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mari, M. Matei, M. G. Ceravolo, A. Pisani, A. Montesi, and L. Provinciali Predictive value of clinical indices in detecting aspiration in patients with neurological disorders J. Neurol. Neurosurg. Psychiatry, October 1, 1997; 63(4): 456 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Drugs for Parkinson's disease reviewed DTB, July 1, 1995; 33(7): 49 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Park and P. O'Neill Management of neurological dysphagia Clinical Rehabilitation, May 1, 1994; 8(2): 166 - 174. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
