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Department of Neurology, Henry Ford Hospital, Detroit, MI (Drs. Dereski and Welch)
Department of Physics, Oakland University, Rochester, MI. (Drs. Chopp, Chen, and Hetzel)
Departments of Pathology, Henry Ford Hospital, Detroit, MI. (Dr. Ho)
Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI. (Ms. Brown)
We heated Wistar rats (n = 10) to 41.5 ± 0.2 °C for 15 minutes, 24 hours before the induction of forebrain cerebral ischemia. We subjected 23 rats to forebrain ischemia without prior heating. Ischemic cell damage in the medial, lateral, and overall CA 1/2 hippocampus, inferior frontal cortex, and dorsal-lateral striatum was significantly (p < 0.05) less severe in heated animals than in nonheated animals.
Address correspondence and reprint requests to Dr. Chopp, Department of Neurology, 2799 W. Grand Boulevard, Henry Ford Hospital, Detroit, MI 48202.
Supported by NCI Grant #CA43892 and NINCDS Grant #NS2339.
Received November 29, 1988. Accepted for publication in final form April 17, 1989.
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