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From the Center for Stroke Research and NMR Center and the Neuropsychology Division, Psychiatry Department (Dr. Brown and Mr. Gdowski), and Neurology Department (Drs. Levine, Gorell, Bueri, Helpern, and Welch), Henry Ford Hospital, Detroit, MI; and the Laboratory of Neurophysica, Department of Psychiatry and Neurology (Dr. Pettegrew), University of Pittsburgh, Pittsburgh, PA.
We used in vivo phosphorus 31 nuclear magnetic resonance (31P NMR) spectroscopy to study regional high-energy phosphate and phospholipid metabolism in brains of patients with dementia associated with probable Alzheimer's disease (AD) and multiple subcortical cerebral infarctions (MSID). The MSID patients demonstrated elevations of the phosphocreatine (PCr)/inorganic orthophosphate (Pi) ratio in both the temporoparietal and frontal regions. Phosphomonoesters (PME) and the ratio of PME to phosphodiesters were elevated in the temporoparietal region of AD. Pi was also elevated in the frontal and temporoparietal regions of AD. Findings from 31P NMR were accurate in distinguishing MSID from AD. Values of PCr/Pi accurately classified 100% of the MSID patients and 92% of AD. Pi and PME, considered jointly, also accurately classified all MSID and all but 1 AD. Findings from in vivo 31P NMR spectroscopy appear to yield metabolic profiles useful in distinguishing AD from MSID.
Address correspondence and reprint requests to Dr. Brown, Neuropsychology Laboratory, Henry Ford Hospital (K-11), 2799 West Grand Boulevard, Detroit, MI 48202.
Supported in part by NIH grant NS23393 and the American Heart Association, Michigan Affiliate.
Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.
Received March 15, 1989. Accepted for publication in final form May 9, 1989.
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