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NEUROLOGY 1989;39:1474
© 1989 American Academy of Neurology

Monozygotic twins discordant for Alzheimer's disease

H. Creasey, MBBS, FRACP, A. Jorm, PhD, W. Longley MA, MSc, G. A. Broe, BA, FRACP, MBBS and A. S. Henderson, MD, FRACP

From the Department of Geriatric Medicine (Drs. Creasey and Broe, and W. Longley), University of Sydney, and the NH & MRC Social Psychiatry Research Unit (Drs. Jorm and Henderson), Australian National University.

We identified 3 pairs of monozygotic twins discordant for probable Alzheimer's disease from a twin register and found no systematic differences in potential risk factor exposures between affected and unaffected twins. Such cases predict a role for environmental factors in the etiology or clinical onset of Alzheimer's disease.

Address correspondence and reprint requests to Dr. Creasey, Department of Geriatric Medicine, Repatriation General Hospital, Concord, NSW, Australia, 2139.

Received February 17, 1989. Accepted for publication in final form May 9, 1989.




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