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Ibuprofen-induced meningitis

Detection of intrathecal IgG synthesis and immune complexes

From the Department of Neurology (Drs. Chez, Sila, and Ransohoff), the Mellen Center for Multiple Sclerosis Treatment and Research (Dr. Ransohoff), and Department of Infectious Diseases (Dr. Longworth), Cleveland Clinic Foundation, Cleveland, OH; and the M. S. Hershey Medical School (Ms. Weida), Hershey, PA.

We report a case of ibuprofen-induced meningitis in an otherwise healthy individual. This is the 1st case documenting intrathecal IgG synthesis and immune complex formation in this disorder. The immunopathogenesis remains obscure, but is suggestive of an antigen-specific process requiring the presence of or exposure to ibuprofen.

Address correspondence and reprint requests to Dr. Sila, Department of Neurology, Cleveland Clinic Foundation, One Clinic Center, Cleveland, OH 44195.

Received February 21, 1989. Accepted for publication in final form June 5, 1989.

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