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NEUROLOGY 1989;39:1619
© 1989 American Academy of Neurology

MRI detects cerebral involvement in neurologically asymptomatic patients with adrenoleukodystrophy

P. Aubourg, MD, N. Sellier, MD, J. L. Chaussain, MD and G. Kalifa, MD

From the Department of Pediatric Endocrinology and Unité INSERM U188 (Drs. Aubourg and Chaussain), and the Department of Pediatric Radiology (Drs. Sellier and Kalifa), Hôpital Saint Vincent de Paul, Paris, France.

X-Linked adrenoleukodystrophy (ALD) is a peroxisomal disorder which affects the white matter of the CNS. MRI detected white matter lesions in 2 of 7 patients with biochemically proven ALD but without neurologic manifestations.

Address correspondence and reprint requests to Dr. Aubourg, Unité INSERM U188, Hôpital Saint Vincent de Paul, 74 avenue Denfert-Rochereau, 75014 Paris, France.

Received March 16, 1989. Accepted for publication in final form May 30, 1989.




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