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A double-blind, placebo-controlled trial of high doses of gangliosides in amyotrophic lateral sclerosis

From the Medical University of South Carolina (Drs. Scott and Goust), Charleston, SC, and University of Colorado (Dr. Seay), Denver, CO.

We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not significantly benefit ALS patients.

Address correspondence and reprint requests to Dr. Scott, Department of Neurology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425.

Presented in part at the forty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received January 20, 1989. Accepted for publication in final form May 31, 1989.

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