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Pattern and concentration of IgG in cerebrospinal fluid in neurosarcoidosis

From the Medical University of South Carolina (D n. Scott and Goust), Charleston, SC. and University of Colorado (Dr. Seay). Denver, CO.

Fteports have suggested that the pattern of CSF IgG dif-ferentiates neurosarcoidosis from multiple sclerosis. We examined CSF and serum of 7 patients with neurosarcoidosis to determine concentrations of IgG and al-bumin and the presence of oligoclonal bands. Our results showed that neurosar-coidosis may have associated abnormalities of IgG synthesis and oligoclonal bands present in CSF, but without a consistent pattern.

Address correspondence and reprint requests to Dr. Scott, Department of Neurology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425.

Presented in part at the forty-first annual meeting of the American Academy of Neurology, Chicago. IL, April 1989.

Received January 20,1989. Accepted for publication in final form May 31.1989.