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NEUROLOGY 1989;39:161
© 1989 American Academy of Neurology

Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis

S. M. Rao, PhD, G. J. Leo, DO, V. M. Haughton, MD, P. St. Aubin-Faubert, MS and L. Bernardin, BS

Department of Neurology, Medical College of Wisconsin, Milwaukee, WI (Drs. Rao and Leo, Ms. St. Aubin-Faubert, and Ms. Bernardin)
Department of Radiology, Medical College of Wisconsin, Milwaukee, WI (Dr. Haughton).

Previous research has suggested that cerebral lesions observed on magnetic resonance imaging (MRI) of MS patients are clinically "silent." We examined the validity of this assertion by correlating neuropsychological test performance with MRI findings in 53 MS patients. We used a semiautomated quantitation system to measure three MRI variables: total lesion area (TLA), ventricular-brain ratio (VBR), and size of the corpus callosum (SCC). Stepwise multiple regression analyses indicated that TLA was a robust predictor of cognitive dysfunction, particularly for measures of recent memory, abstract/conceptual reasoning, language, and visuospatial problem solving. SCC predicted test performance on measures of mental processing speed and rapid problem solving, while VBR did not independently predict cognitive test findings. These findings suggest that cerebral lesions in MS produce cognitive dysfunction and that MRI may be a useful predictor of cognitive dysfunction.

Address correspondence and reprint requests to Dr. Rao, Section of Neuropsychology, Medical College of Wisconsin, 1000 North 92nd Street, Milwaukee, WI 53226.

Supported in part by a Research Career Development Award (K04 NS01055) and a research grant (R01 NS22128) from NINCDS to Dr. Rao.

Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.

Received May 2, 1988. Accepted for publication in final form August 8, 1988.




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J. M. Peyser, S. M. Rao, N. G. LaRocca, and E. Kaplan
Guidelines for Neuropsychological Research in Multiple Sclerosis
Arch Neurol, January 1, 1990; 47(1): 94 - 97.
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W. W. Beatty, D. E. Goodkin, N. Monson, and P. A. Beatty
Cognitive Disturbances in Patients With Relapsing Remitting Multiple Sclerosis
Arch Neurol, October 1, 1989; 46(10): 1113 - 1119.
[Abstract] [PDF]


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