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Extended major histocompatibility complex haplotypes in patients with multiple sclerosis

Neuroimmunology Unit, Massachusetts General Hospital, Boston, MA (Dr. Hauser)
Center for Blood Research and Department of Pediatrics and Pathology, Harvard Medical School, Boston, MA (Drs. Fleischnick, Awdeh, Yunis, and Alper, and Ms. Marcus)
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA (Dr. Weiner).

We derived complete haplotypes of the major histocompatibility complex for 33 patients with MS and their families. The DR2 allele and DR2-bearing extended haplotypes, in proportion, were overrepresented on chromosomes of MS patients compared with parental chromosomes not transmitted to MS offspring. We did not confirm previous reports that particular alleles at the BF locus are overrepresented in MS or that C2 hypocomplementemia is present. These results suggest that the DR2 allele is a risk factor for MS, and not merely a genetic marker of the population of origin.

Address correspondence and reprint requests to Dr. Hauser, Neuroimmunology Unit, Massachusetts General Hospital, Fruit Street, Boston, MA 02114.

Supported by National Institutes of Health grants AI-14157, DK-26844, CA-20531, CA-06516, HD-17461, and HL-29583, the Upjohn Corporation, and a grant from the American Red Cross. Dr. Hauser is a Harry Weaver Neuro-science Scholar of the National Multiple Sclerosis Society.

Received June 10, 1988. Accepted for publication in final form August 19, 1988.

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