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Absence of Immorally mediated damage within the central nervous system of AIDS patients

Laboratory Department, Naval Hospital, San Diego, La Jolla, CA (Dr. Lenhardt)
Department of Pathology (Neuropathology), University of California San Diego, La Jolla, CA (Dr. Wiley).

The pathogenesis of CNS damage by human immunodeficiency virus infection is unclear. Because there is little detectable virus within the CNS, we evaluated the role of the humoral immune system in mediating CNS tissue destruction. The paucity and nonspecific nature of immunoglobulin deposition rules against significant involvement of humorally mediated injury in the pathogenesis of AIDS encephalopathy.

Address correspondence and reprint requests to Dr. Wiley, Department of Pathology (Neuropathology) M-012, University of California San Diego, La Jolla, CA 92093.

Received July 1, 1988. Accepted for publication in final form August 19, 1988.

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