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Occurrence of both neurofibromatoses 1 and 2 in the same individual with a rapidly progressive course

Department of Neurology, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

We describe a family in which the father had neurofibromatosis-1 and the mother neurofibromatosis-2. Their son presented at the age of 8 years with bilateral acoustic neuromas, meningioma, and numerous neurofibromas. We believe that the occurrence of the genes responsible for both forms of neurofibromatosis in the same patient had a synergistic effect on the early rapid growth of neurofibromatoses 1 and 2 neoplasms.

Address correspondence and reprint requests to Dr. Sadeh, Department of Neurology, Sheba Medical Center, Tel Hashomer 52621, Israel.

Received May 16, 1988. Accepted for publication in final form August 23, 1988.

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