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NEUROLOGY 1989;39:288
© 1989 American Academy of Neurology

A case of Alzheimer's disease and hippocampal sclerosis with normal cholinergic activity in basal forebrain, neocortex, and hippocampus

Richard M. Zweig, MD, Kathleen M. Schegg, PhD, John H. Peacock, MD, PhD and David Melarkey, BA

Departments of Internal Medicine (Neurology Division) and Anatomy of the University of Nevada School of Medicine and the VA Medical Center, Reno, NV.

A 76-year-old man without apparent dementia met pathologic criteria at autopsy for Alzheimer's disease, which included a maximum senile plaque density greater than 15 per square millimeter of neocortex. Despite hippocampal sclerosis, changes typical of Alzheimer's disease were not found in this region or in basal forebrain. Choline acetyltransferase activity in hippocampus, septum, and parietal cortex was normal.

Address correspondence and reprint requests to Dr. Zweig, VA Medical Center, 1000 Locust St., Reno, NV 89520.

Supported by research funding from the Medical Research Service, Veterans Administration; the University of Nevada, Reno; the University of Nevada School of Medicine; and the Robert Z. Hawkins Foundation.

Received July 1, 1988. Accepted for publication in final form August 29, 1988.




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