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NEUROLOGY 1989;39:465
© 1989 American Academy of Neurology

Molecular and clinical correlations of deletions leading to Duchenne and Becker muscular dystrophies

L. L. Baumbach, PhD, J. S. Chamberlain, PhD, P. A. Ward, MS, N. J. Farwell, BS and C. T. Caskey, MD

Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX (Drs. Baumbach, Chamberlain, and Caskey, and PA Ward and NJ Farwell)
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX (Dr. Caskey).

Human DMD cDNA probes have been used to delineate possible deletions in 160 affected males. Approximately 56% of these individuals had detectable deletions, 29% of which mapped to a region centered around 500 kb from the 5' end of the gene whereas 69% mapped to a region located centrally 1,200 kb from the 5' end. We have observed no correlation between the extent of a deletion, its location, and clinical severity of the associated disease. For some cases with deletions in the two high-frequency deletion regions, the predicted effect upon translational reading frame of the resultant dystrophin mRNA did not correlate with the associated disease phenotype.

Address correspondence and reprint requests to Dr. Baumbach, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

L.L.B. is, and J.S.C. was, supported by postdoctoral fellowships from the Muscular Dystrophy Association during the duration of these studies. Supported by a Task Force on Genetics Grant from the Muscular Dystrophy Association.

Received November 14, 1988. Accepted for publication in final form December 23, 1988.




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