Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brooke, M. H.
Right arrow Articles by Arfken, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brooke, M. H.
Right arrow Articles by Arfken, C.
NEUROLOGY 1989;39:475
© 1989 American Academy of Neurology

Duchenne muscular dystrophy

Patterns of clinical progression and effects of supportive therapy

M. H. Brooke, MD, G. M. Fenichel, MD, R. C. Griggs, MD, J. R. Mendell, MD, R. Moxley, MD, J. Florence, MS, W. M. King, LPT, S. Pandya, MS, J. Robison, BS, J. Schierbecker, PT, L. Signore, RN, J. P. Miller, AB, B. F. Gilder, MD, K. K. Kaiser, S. Mandel, BA and C. Arfken, PhD

Department of Neurology, Washington University School of Medicine, St. Louis, MO (Drs. Brooke and Gilder, and J. Florence, J. Schierbecker, and K.K. Kaiser)
Department of Biostatistics, Washington University School of Medicine, St. Louis, MO (J.P. Miller, S. Mandel, and Dr. Arfken)
Departments of Neurology, Vanderbilt University, Nashville, TN (Dr. Fenichel and J. Robison)
Ohio State University, Columbus, OH (Dr. Mendell, and W.M. King and L. Signore)
University of Rochester, Rochester, NY (Drs. Griggs and Moxley, and S. Pandya).

Two-hundred eighty-three boys with Duchenne dystrophy and 10 with Becker dystrophy have been followed for up to 10 years in a protocol that accurately measured their function, strength, contractures, and back curvature. Clinical heterogeneity is noted. Patients whose muscles were stronger were more likely to die from a cardiomyopathy. Weaker patients died from respiratory failure. A series of milestones is defined, which is of use in following the illness in an individual patient. This approach permits a scoring system that allows the severity of the disease to be defined in an individual boy. Evaluation of physical therapy and surgical intervention shows that night splints and scoliosis surgery are effective forms of treatment.

Address correspondence and reprint requests to Dr. Brooke, Division of Neurology, Room 2E3.12, Walter C. McKenzie Center Health Sciences, Edmonton, Alberta, Canada T6G 2R3.

Supported by a grant from the Muscular Dystrophy Association and Public Health Research Grant No. RR-36 from the General Clinical Research Center Branch, Division of Research Facilities and Resources, Bethesda, MD.

Received September 7, 1988. Accepted for publication in final form October 24, 1988.




This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
T. A. L. Wren, S. Bluml, L. Tseng-Ong, and V. Gilsanz
Three-Point Technique of Fat Quantification of Muscle Tissue as a Marker of Disease Progression in Duchenne Muscular Dystrophy: Preliminary Study
Am. J. Roentgenol., January 1, 2008; 190(1): W8 - W12.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
B. S. Russman
Spinal Muscular Atrophy: Clinical Classification and Disease Heterogeneity
J Child Neurol, August 1, 2007; 22(8): 946 - 951.
[Abstract] [PDF]

Home page
 NeurologyHome page
W. M. King, R. Ruttencutter, H. N. Nagaraja, V. Matkovic, J. Landoll, C. Hoyle, J. R. Mendell, and J. T. Kissel
Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy
Neurology, May 8, 2007; 68(19): 1607 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
R. M Lovering, N. C Porter, and R. J Bloch
The Muscular Dystrophies: From Genes to Therapies
Physical Therapy, December 1, 2005; 85(12): 1372 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. L. Jefferies, B. W. Eidem, J. W. Belmont, W. J. Craigen, S. M. Ware, S. D. Fernbach, S. R. Neish, E. O. Smith, and J. A. Towbin
Genetic Predictors and Remodeling of Dilated Cardiomyopathy in Muscular Dystrophy
Circulation, November 1, 2005; 112(18): 2799 - 2804.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Kohler, C. F. Clarenbach, L. Boni, T. Brack, E. W. Russi, and K. E. Bloch
Quality of Life, Physical Disability, and Respiratory Impairment in Duchenne Muscular Dystrophy
Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 1032 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. C. Griggs and K. Bushby
Continued need for caution in the diagnosis of Duchenne muscular dystrophy
Neurology, May 10, 2005; 64(9): 1498 - 1499.
[Full Text] [PDF]

Home page
 NeurologyHome page
R. T. Moxley III, S. Ashwal, S. Pandya, A. Connolly, J. Florence, K. Mathews, L. Baumbach, C. McDonald, M. Sussman, and C. Wade
Practice Parameter: Corticosteroid treatment of Duchenne dystrophy: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society
Neurology, January 11, 2005; 64(1): 13 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Respiratory Care of the Patient with Duchenne Muscular Dystrophy: ATS Consensus Statement
Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 456 - 465.
[Full Text] [PDF]

Home page
 NeurologyHome page
M. A. Tarnopolsky, D. J. Mahoney, J. Vajsar, C. Rodriguez, T. J. Doherty, B. D. Roy, and D. Biggar
Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy
Neurology, May 25, 2004; 62(10): 1771 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
J. E. Bothwell, K. E. Gordon, J. M. Dooley, J. Mac Sween, E. A. Cummings, and S. Salisbury
Vertebral Fractures in Boys with Duchenne Muscular Dystrophy
Clinical Pediatrics, May 1, 2003; 42(4): 353 - 356.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. F. PHILLIPS, R. C. M. QUINLIVAN, R. H. T. EDWARDS, and P. M. A. CALVERLEY
Changes in Spirometry Over Time as a Prognostic Marker in Patients with Duchenne Muscular Dystrophy
Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2191 - 2194.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Saito, D. Kobayashi, M. Komatsu, T. Yajima, A. Yagihashi, Y. Ishikawa, R. Minami, and N. Watanabe
A Sensitive Assay of Tumor Necrosis Factor {alpha} in Sera from Duchenne Muscular Dystrophy Patients
Clin. Chem., October 1, 2000; 46(10): 1703 - 1704.
[Full Text] [PDF]

Home page
 Clin RehabilHome page
J P J Bakker, I J M de Groot, H Beckerman, B A de Jong, and G J Lankhorst
The effects of knee-ankle-foot orthoses in the treatment of Duchenne muscular dystrophy: review of the literature
Clinical Rehabilitation, April 1, 2000; 14(4): 343 - 359.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. F. PHILLIPS, P. E. M. SMITH, N. CARROLL, R. H. T. EDWARDS, and P. M. A. CALVERLEY
Nocturnal Oxygenation and Prognosis in Duchenne Muscular Dystrophy
Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 198 - 202.
[Abstract] [Full Text]

Home page
 JBJSHome page
P. J. VIGNOS JR., M. B. WAGNER, B. KARLINCHAK, and B. KATIRJI
Evaluation of a Program for Long-Term Treatment of Duchenne Muscular Dystrophy. Experience at the University Hospitals of Cleveland
J. Bone Joint Surg. Am., December 1, 1996; 78(12): 1844 - 52.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by AAN Enterprises, Inc.