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Neurofibromatosis and other disorders among children with CNS tumors and their families

Bureau of Cancer Epidemiology, Division of Epidemiology, New York State Department of Health, Albany, NY (Drs. Baptiste and Nasca, and B. Metzger, N. Field, P. MacCubbin, and K. Carlton)
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD (Dr. Greenwald)
Armed Forces Institute of Pathology, Washington, DC (Dr. Armbrustmacher)
Division of Neurosurgery, Albany Medical College, Albany, NY (Dr. Waldman).

We conducted a population-based case-control study with 338 patients, less than 15 years of age, diagnosed with a primary tumor of the central nervous system from January 1968 through December 1977 in 53 New York State counties. The study also included 676 controls selected from the birth certificate files of the New York State Department of Health. We collected information on neuronbromatosis and congenital anomalies in study subjects, their siblings and parents by telephone interview with the mother of each case and control. We obtained supplemental information on neuronbromatosis in the patients and their families from hospital medical records. This study confirmed the strong association of neurofibromatosis with risk of CNS tumors. Thirteen cases and no controls had neurofibromatosis. Two fathers and 3 mothers of cases had neurofibromatosis. Five cases had siblings with neurofibromatosis. None of the first-degree relatives of controls had neurofibromatosis. We observed a relative risk of 4.49 for history of seizures. Seizures are often among the presenting symptoms for CNS tumors. We observed no difference between cases and controls in the occurrence of congenital anomalies. There was a nonsignificant excess of congenital anomalies among siblings of cases compared with controls. This decreased to 1.13 when adjusted for number of siblings.

Address correspondence and reprint requests to Dr. Baptiste, Cancer Etiology Unit, Bureau of Cancer Epidemiology, Division of Epidemiology, New York State Department of Health, Coming Tower, Albany, NY 12237.

Supported by a grant (1 RO CA 26194) from the National Cancer Institute, US Public Health Service.

Received August 9, 1988. Accepted for publication in final form October 24, 1988.

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