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NMR Center and Center for Stroke Research, Department of Neurology, Henry Ford Hospital, Detroit, MI (Drs. Welch, Levine, and Helpern)
Divieion of Bio statistics, Vicenza Hospital, Vicenza, Italy (Ms. Schultz)
Department of Neurology, Vicenza Hospital, Vicenza, Italy (Dr. D'Andres).
We measured brain energy phosphate metabolism and intracellular pH (pH1) in a cross-sectional study of migraine patients by in vivo phosphorus 31 NMR spectroscopy. During a migraine attack the ratio ATP/total phosphate signal (mole % ATP) was preserved, but there waa a decrease in mole % phosphocreatine (PCr) and an increase in mole % inorganic phosphate (Pi) resulting in a decrease of the PCr/Pi ratio, an index of brain phosphorylation potential. This was found in chic but not common migraine. Mole % Pi waa also increased in combined brain regions between attacks. There waa no alteration in brain pH1 during or between attacks. Energy phosphate metabolism but not pH1 appears disordered during a migraine attack.
Address correspondence and reprint requestn to Dr. Welch, Depertment of Neurology, K-11, Henry Ford Hospital. 2799 West Grand Boulevard, Detroit, MI 48202.
Supported in part by NIH grant # NS23393 (to K.M.A.W.) and Henry Ford Hospital.
Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.
Received February 25,1988. Accepted for publication in tonal form October 20, 1988.
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