Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Welch, K.M.A.
Right arrow Articles by Helpern, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Welch, K.M.A.
Right arrow Articles by Helpern, J. A.
NEUROLOGY 1989;39:538
© 1989 American Academy of Neurology

Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy

K.M.A. Welch, MD, S. R. Levine, MD, G. D'Andrea, MD, L. R. Schultz, MS and J. A. Helpern, PhD

NMR Center and Center for Stroke Research, Department of Neurology, Henry Ford Hospital, Detroit, MI (Drs. Welch, Levine, and Helpern)
Divieion of Bio statistics, Vicenza Hospital, Vicenza, Italy (Ms. Schultz)
Department of Neurology, Vicenza Hospital, Vicenza, Italy (Dr. D'Andres).

We measured brain energy phosphate metabolism and intracellular pH (pH1) in a cross-sectional study of migraine patients by in vivo phosphorus 31 NMR spectroscopy. During a migraine attack the ratio ATP/total phosphate signal (mole % ATP) was preserved, but there waa a decrease in mole % phosphocreatine (PCr) and an increase in mole % inorganic phosphate (Pi) resulting in a decrease of the PCr/Pi ratio, an index of brain phosphorylation potential. This was found in chic but not common migraine. Mole % Pi waa also increased in combined brain regions between attacks. There waa no alteration in brain pH1 during or between attacks. Energy phosphate metabolism but not pH1 appears disordered during a migraine attack.

Address correspondence and reprint requestn to Dr. Welch, Depertment of Neurology, K-11, Henry Ford Hospital. 2799 West Grand Boulevard, Detroit, MI 48202.

Supported in part by NIH grant # NS23393 (to K.M.A.W.) and Henry Ford Hospital.

Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.

Received February 25,1988. Accepted for publication in tonal form October 20, 1988.




This article has been cited by other articles:


Home page
 NeurologyHome page
C. Di Lorenzo, F. Pierelli, G. Coppola, G. S. Grieco, C. Rengo, M. Ciccolella, D. Magis, M. Bolla, C. Casali, F. M. Santorelli, et al.
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs
Neurology, May 5, 2009; 72(18): 1588 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
M. Rocca, E Pagani, B Colombo, P Tortorella, A Falini, G Comi, and M Filippi
Selective Diffusion Changes of The Visual Pathways in Patients with Migraine: A 3-T Tractography Study
Cephalalgia, October 1, 2008; 28(10): 1061 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
G Coppola, F Pierelli, and J Schoenen
Is The Cerebral Cortex Hyperexcitable or Hyperresponsive in Migraine?
Cephalalgia, December 1, 2007; 27(12): 1427 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
S. Aurora and F Wilkinson
The Brain is Hyperexcitable in Migraine
Cephalalgia, December 1, 2007; 27(12): 1442 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
U. G. Schulz, A. M. Blamire, R. G. Corkill, P. Davies, P. Styles, and P. M. Rothwell
Association between cortical metabolite levels and clinical manifestations of migrainous aura: an MR-spectroscopy study
Brain, December 1, 2007; 130(12): 3102 - 3110.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
S Scarrone, M Podesta, A Cupello, C Finocchi, F Frassoni, C Gandolfo, and M Balestrino
Abnormalities of Na/K ATPase in Migraine With Aura
Cephalalgia, February 1, 2007; 27(2): 128 - 132.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
M Sparaco, M Feleppa, R. Lipton, A. Rapoport, and M. Bigal
Mitochondrial Dysfunction and Migraine: Evidence and Hypotheses
Cephalalgia, April 1, 2006; 26(4): 361 - 372.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
P. Sandor, U Dydak, J Schoenen, S. Kollias, K Hess, P Boesiger, and R. Agosti
MR-Spectroscopic Imaging during Visual Stimulation in Subgroups of Migraine with Aura
Cephalalgia, July 1, 2005; 25(7): 507 - 518.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. S. Sandor, L. Di Clemente, G. Coppola, U. Saenger, A. Fumal, D. Magis, L. Seidel, R. M. Agosti, and J. Schoenen
Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
Neurology, February 22, 2005; 64(4): 713 - 715.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K.M. A. Welch
Contemporary concepts of migraine pathogenesis
Neurology, October 28, 2003; 61(90084): S2 - 8.
[Abstract] [Full Text]

Home page
 CephalalgiaHome page
A Ambrosini, A. de Noordhout, P. Sandor, and J Schoenen
Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations
Cephalalgia, May 1, 2003; 23(1_suppl): 13 - 31.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
C. Marini, I. Ciancarelli, and M. G. Tozzi-Ciancarelli
Authors' Reply: The Role of Helicobacter Pylori Infection in Migraine
Cephalalgia, April 1, 2003; 23(3): 240 - 241.
[Full Text] [PDF]

Home page
 CephalalgiaHome page
S. Silberstein and P. Goadsby
Migraine: Preventive Treatment
Cephalalgia, September 1, 2002; 22(7): 491 - 512.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. D. Boska, K. M.A. Welch, P. B. Barker, J. A. Nelson, and L. Schultz
Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes
Neurology, April 23, 2002; 58(8): 1227 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
V. Bohotin, A. Fumal, M Vandenheede, P. Gerard, C. Bohotin, A. Maertens de Noordhout, and J. Schoenen
Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine
Brain, April 1, 2002; 125(4): 912 - 922.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. M. McKendrick, A. J. Vingrys, D. R. Badcock, and J. T. Heywood
Visual Dysfunction between Migraine Events
Invest. Ophthalmol. Vis. Sci., March 1, 2001; 42(3): 626 - 633.
[Abstract] [Full Text]

Home page
 CephalalgiaHome page
D. Dodick, T. Rozen, P. Goadsby, and S. Silberstein
Cluster Headache
Cephalalgia, November 1, 2000; 20(9): 787 - 803.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
S. Read, M. Smith, A. Hunter, N Upton, and A. Parsons
SB-220453, A Potential Novel Antimigraine Agent, Inhibits Nitric Oxide Release Following Induction of Cortical Spreading Depression in the Anaesthetized Cat
Cephalalgia, March 1, 2000; 20(2): 92 - 99.
[Abstract] [Full Text] [PDF]

Home page
 CephalalgiaHome page
K Shibata, M Osawa, and M Iwata
Pattern Reversal Visual Evoked Potentials in Migraine with Aura and Migraine Aura Without Headache
Cephalalgia, August 1, 1998; 18(6): 319 - 323.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
W Wang and J Schoenen
Interictal Potentiation of Passive "Oddball" Auditory Event-Related Potentials in Migraine
Cephalalgia, June 1, 1998; 18(5): 261 - 265.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
C. Rozell, W. Sibbitt Jr, and W. Brooks
Structural and Neurochemical Markers of Brain Injury in the Migraine Diathesis of Systemic Lupus Erythematosus
Cephalalgia, May 1, 1998; 18(4): 209 - 215.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
M. Tozzi-Ciancarelli, G De Matteis, C Di Massimo, C Marini, I Ciancarelli, and A Carolei
Oxidative Stress and Platelet Responsiveness in Migraine
Cephalalgia, August 1, 1997; 17(5): 580 - 584.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
V Pfaffenrath, P Wessely, C Meyer, H. Isler, S Evers, K. Grotemeyer, Z Taneri, D Soyka, H G"bel, and M Fischer
Magnesium in the Prophylaxis of Migraine--a Double-Blind, Placebo-Controlled Study
Cephalalgia, October 1, 1996; 16(6): 436 - 440.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
M Wilkinson, V Pfaffenrath, J Schoenen, H-C Diener, and T. Steiner
Migraine and Cluster Headache-Their Management with Sumatriptan: A Critical Review of The Current Clinical Experience
Cephalalgia, October 1, 1995; 15(5): 337 - 357.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
P Montagna
Magnetic Resonance Spectroscopy in Migraine
Cephalalgia, August 1, 1995; 15(4): 323 - 327.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
J Schoenen, M Lenaerts, and E Bastings
High-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study
Cephalalgia, October 1, 1994; 14(5): 328 - 329.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
P Montagna, P Cortelli, and B Barbiroli
Magnetic Resonance Spectroscopy Studies in Migraine
Cephalalgia, June 1, 1994; 14(3): 184 - 193.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. M. Minderhoud, E. L. Mooyaart, R. L. Kamman, A. W. Teelken, M. C. Hoogstraten, L. M. Vencken, E. J.s Gravenmade, and W. van den Burg
In Vivo Phosphorus Magnetic Resonance Spectroscopy in Multiple Sclerosis
Arch Neurol, February 1, 1992; 49(2): 161 - 165.
[Abstract] [PDF]

Home page
 CephalalgiaHome page
E. Presedo, B Barbiroli, P Montagna, P Cortelli, and T.-M. Wallasch
Letters to the Editor
Cephalalgia, July 1, 1991; 11(3): 161 - 163.
[PDF]

Home page
 Arch NeurolHome page
R. F. Deicken, B. Hubesch, P. C. Jensen, D. Sappey-Marinier, P. Krell, A. Wisniewski, D. Vanderburg, R. Parks, G. Fein, and M. W. Weiner
Alterations in Brain Phosphate Metabolite Concentrations in Patients With Human Immunodeficiency Virus Infection
Arch Neurol, February 1, 1991; 48(2): 203 - 209.
[Abstract] [PDF]