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Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease

Kinaman Laboratory of Neurological Remarch, Department of Psychiatry, Canada (Drs. Akiyarrm McCser, and E.G. McGeer)
Division of Neurology, Department of Medicine (Dr. Peppard), University of British Columbia, Vancouver, Canada
School of Computer Science, Simon Fraser University, Burnnby, British Columbia, Canada (Dr. Harrow).

We detected croased cerebellar as well as uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease by positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose. We studied a series of 26 consecutive, clinically diagnosed Alzheimer cases, including 6 proven by later autopsy, and compared them with 9 age-matched controls. We calculated asymmetry indices (AIs) of cerebral metabolic rate for matched left-right regions of interest (ROIs) and determined the extent of diaschisis by correlative analyses. For the Alzheimer pup, we found cerebellar Ah correlated negatively, and thalamic AIs positively, with those of the cerebral hemisphere and fmntal, temporal, parietal, and angular cortices, while basal ganglia AIs correlated positively with frontal cortical AIs. The only significant correlation of AIs for normal subject a was between the thalamus and cerebral hemisphere. These data indicate that PET is a sensitive technique for detecting diaschisis.

Address correspondence and reprint requests to Dr. P.L. McGeer, University of British Columbia, Kinsmen Laboratory of Neurological Research, 2255 Wesbrook Mall, Vancouver, BC, Canada, V6T 1W5.

Supported by two program grants from the Medical Research Council of Canada and a grant from the Alzheimer Society of British Columbia.

Received July 14, 1988. Accepted for publication in final form October 10, 1988.

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