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NEUROLOGY 1989;39:557
© 1989 American Academy of Neurology

Cognitive impairments associated with early Parkinson's disease

Bonnie E. Levin, PhD, Maria M. Llabre, PhD and William J. Weiner, MD

Department of Neurology, University of Miami, School of Medicine, Miami, FL (Drs. Levin and Weiner)
Department of Psychology, University of Miami, Coral Gables, FL (Dr. Llabre).

We administered a battery of cognitive tests to 41 recently diagnosed Parkinson patients and 41 controls to assess the early neuropsychological changes associated with Parkinson's disease (PD). Parkinson subjects did as well as controls on tasks assessing attention and select language and visuospatial measures. However, PD subjects did significantly worse on embedded figures, facial recognition, proverbs, and verbal and figural memory measures, and made more perseverative responses on a set shifting task. A discriminant function of measures of proverbs, embedded figures, and memory accounted for 22% of the variance between groups. These data suggest that the cognitive changes in early PD are more pervasive than originally described and may reflect the onset of a more widespread pathologic process.

Address correspondence and reprint requests to Dr. Levin, Department of Neurology (D4-5). University of Miami, School of Medicine, P.O. Box 016960, Miami, FL 33101.

Supported in part by the National Parkinson Foundation.

Received June 16,1988. Accepted for publication in final form October 25.1988.




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