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NEUROLOGY 1989;39:598
© 1989 American Academy of Neurology

Carbamazepine in Fabry's disease

Effective analgesia with dose-dependent exacerbation of autonomic dysfunction

M. R. Filling-Katz, MD, H. F. Merrick, MD, PhD, J. K. Fink, MD, R. B. Miles, MD, J. Sokol, MD and N. W. Barton, MD, PhD

Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, MD (Drs. Filling-Katz, Merrick, Fink, Sokol. and Barton)
Human Motor Control Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD (Dr. Miles).

Seven patients with Fabry's disease and severe pain received carbamazepine (CMZ). Five of 7 patients had moderate to complete relief baaed upon self-assessment of pain levels. Preexisting autonomic dysfunction was exacerbated by CMZ in 2. Complications encountered were ileus, urinary retention, and gastrointestinal disturbance. Although CMZ was useful in treatment of pain, caution should be employed in this disease.

Address correspondence and reprint requests to Dr. Filling-Katz, Rm. 3D04, Bldg. 10, National Institutes of Health, Bethesda, MD 20896.

Received August 26, 1988. Accepted for publication in final form October 31, 1988.




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