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NEUROLOGY 1989;39:644
© 1989 American Academy of Neurology

Heterotopic neurons in spinal cord of patients with ALS

Mark A. Kozlowski, BS, Celia Williams, BS, David R. Hinton, MD and Carol A. Miller, MD

Department of Pathology, University of Southern California School of Medicine, Los Angeles, (Mr. Kozlowski, Ms. Williams, and Drs. Hinton and Miller)
Department of Biology, California Institute of Technology, Pasadena CA.(Drs. Hinton and Miller)

Monoclonal antibody 44.1, an immunocytochemical marker for neurons, identified heterotopically located, multipolar neurons deep within the spinal cord white matter of patients with amyotrophic lateral sclerosis. Displaced neurons were most numerous in the ventral outflow and lateral corticospinal tract regions of all cord levels. These changes may be the result of aberrant neuronal migration during spinal cord development.

Address correspondence and reprint requests to Dr. Miller, Department of Pathology, University of Southern California School of Medicine, 2011 Zonal Avenue, McKibben Annex 345, Los Angeles, CA 90033.

Funded in part by the Muscular Dystrophy Association (C.A.M.), the Barbara Vanderbilt Peck Foundation of the Amyotrophic Lateral Sclerosis Society of America (C.A.M.), National Institute of Mental Health (R01-MH 39145, C.A.M.), National Institute for Aging (P50-AG 05142, C.A.M.), the Gordon Ross Foundation (D.R.H.), and the Medical Research Council of Canada (D.R.H.).

Received October 13, 1988. Accepted for publication in final form November 16, 1988.






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