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NEUROLOGY 1989;39:655
© 1989 American Academy of Neurology

Selenium metabolism and supplementation in patients with muscular dystrophy

M. J. Jackson, PhD, J. Coakley, MB, MRCP, M. Stokes, PhD, R.H.T. Edwards, PhD, FRCP and O. Oster, PhD

Muscle Research Centre, Department of Medicine, University of Liverpool, Liverpool, UK (Drs. Jackson, Coakley, Stokes, and Edwards)
Abteilung Fur Klinische Chemie und Laboratoriumsmedizin, Universitat Klinik Mainz, Mainz, FRG. (Dr. Oster)

We studied selenium metabolism in patients with Duchenne muscular dystrophy and in contrast to previous reports found no significant abnormalities in these patients. Supplementation of muscular dystrophy patients and control subjects with sodium selenite (1 mg selenium/day) induced a variable rise in the activity of the selenium-dependent enzyme glutathione peroxidase in plasma and red cells, but no significant change in muscle glutathione peroxidase activities. There was no effect of selenium supplementation on disease activity in the patients with muscular dystrophy. Thiobarbituric acid-reacting substances (an index of free radical-mediated lipid peroxidation) were elevated in the muscle of patients with Duchenne muscular dystrophy in contrast to patients with other forms of muscular dystrophy and control subjects. This elevation was unaffected by selenium supplementation.

Address correspondence and reprint requests to Dr. Jackson, Muscle Research Centre, Department of Medicine, University of Liverpool, PO Box 147, Liverpool L693BX.UK.

Supported in part by the Muscular Dystrophy Group of Great Britain and Northern Ireland.

Received May 6, 1988. Accepted for publication in final form November 2, 1988.






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