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Use of ³¹P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia

Departments of Pediatrics and Radiology, University of Texas Southwestern Medical Center, Dallas, TX.

We investigated postasphyxial brain damage with ³¹P magnetic resonance spectroscopy (MRS) and correlated it with neurologic assessment and standard laboratory evaluation during the first 10 months of life in 1 infant, baby G. We compared these observations to ³¹P MRS data from 7 healthy term newborns, 1 normal infant examined serially over the first 8.5 months of life, and 5 other term infants following perinatal asphyxia. MRS noninvasively provides biochemical correlates of the evolution of brain damage following perinatal asphyxia and suggests that pH derived from the inorganic phosphate peak may serve as a marker for brain injury.

Address correspondence and reprint requests to Dr. Laptook, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9063.

Supported by funding from Diasonica, Inc. and the National Institutes of Health Southwest In Vivo Resource Facility under grant P41 RR02584. Fellowship support for Ronald Corbett was provided by the Medical Research Council of Canads and the Department of Pediatrics.

Received May 24, 1988. Accepted for publication in final form November 2, 1988.

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