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NEUROLOGY 1989;39:743
© 1989 American Academy of Neurology

Nerve conduction study of human tetrodotoxication

Kenichiro Oda, MD, Kazukuni Araki, MD, Tadahide Totoki, MD and Hiroshi Shibasaki, MD

Department of Internal Medicine (Division of Neurology) Saga Medical School, Sega, Japan (Drs. Oda and Shibasaki).
Department of Anesthesiology, Saga Medical School, Sega, Japan(Dr. Araki and Totoki).

We carried out serial nerve conduction studies in a patient with tetrodotoxication caused by ingesting pufferfish. Conduction velocities and amplitudes of muscle and sensory nerve action potentials were equally affected. Neither temporal dispersion nor focal conduction block occurred. The proximal (F wave) motor latencies were also prolonged. These abnormalities rapidly improved in parallel with clinical recovery and with the decrease in the urinary excretion of tetrodotoxin (TTX). These results indicate that TTX equally and reversibly affects myelinated nerve fibers throughout the entire length of the axon by lowering the conductance of sodium currents at nodes of Ranvier.

Address correspondence and reprint requests to Dr. Oda, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187, Japan.

Received July 15, 1988. Accepted for publication in final form November 21, 1988.




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