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Borrelia burgdorferi antibodies in multiple sclerosis patients

Department of Neurology, Health Sciences Center, SUNY at Stony Brook, Stony Brook, NY.

Lyme disease is said to produce a late syndrome resembling multiple sclerosis. We analyzed serum antibodies to Borrelia burgdorferi in 100 patients referred for possible MS. All lived in an area endemic for Lyme disease. Only 1 of 89 definite MS patients and 2 of 11 non-MS patients were antibody positive. Infection with Borrelia burgdorferi is rare in MS, and Lyme disease is unlikely to play a significant role in the differential diagnosis of MS.

Address correspondence and reprint requests to Dr. Coyle, Department of Neurology, HSC T-12, SUNY at Stony Brook, Stony Brook, NY 11794.

Received November 3, 1988. Accepted for publication in final form January 12, 1989.