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NEUROLOGY 1989;39:825
© 1989 American Academy of Neurology

A case-control study of multiple sclerosis

Eva A. Operskalski, PhD, Barbara R. Visscher, MD, Roberta M. Malmgren, PhD and Roger Detels, MD

Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA
Division of Epidemiology, Department of Public Health, University of California, Los Angeles, CA (Drs. Visscher. Malmgren, and Detels).

We conducted a study of 145 persons with multiple sclerosis who had been identified in a 1970 survey and 145 friend controls, to investigate whether the development of MS was associated with exposure to uncommon viruses or an older age at infection with 1 or more common viruses. The most striking finding was a strong positive association for history of infectious mononucleosis (IM), suggesting older age at exposure to Epstein-Barr virus, the most common etiologic agent of IM. We also found significant positive associations for number of different domiciles before adulthood and for visits outside the United States; both would be compatible with an increased likelihood among cases of exposures to uncommon viruses or to multiple strains of a common agent. Cases were younger at menarche, increasing the probability of viral exposure after puberty.

Address correspondence and reprint requests to Dr. Operskalski, USC School of Medicine, Edmondson Building, Room 111, 1840 North Soto Street, Los Angeles, CA 90032.

Supported by grant no. 5R01 NS 18317 from the National Institute of Neurologic and Communicative Disorders and Stroke, National Institutes of Health.

Received June 23, 1988. Accepted for publication in final form December 21, 1988.




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