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NEUROLOGY 1989;39:844
© 1989 American Academy of Neurology

Absence of genetic linkage of Charcot-Marie-Tooth disease (HMSN Ia) with chromosome 1 gene markers

P. Raeymaekers, MS, P. De Jonghe, MD, H. Backhovens, A. Wehnert, G. De Winter, L. Swerts, MD, J. Gheuens, MD, J.-J. Martin, MD, A. Vandenberghe, PhD and C. Van Broeckhoven, PhD

Department of Biochemistry, University of Antwerp, Antwerpen, Belgium (P. Raeymaekers, H. Backhovens, A. Wehnert, G. De Winter, and Drs. Vandenberghe and Van Broeckhoven)
Department of Neurology and Neuropathology and Born Bunge Foundation, University of Antwerp, Antwerpen, Belgium (Drs. De Jonghe, Swerts, Gheuens, and Martin)
Innogenetics, Gent, Belgium (H. Backhovens, A. Wehnert, and G. De Winter).

We previously reported a large Charcot-Marie-Tooth family not linked to the Duffy blood group marker, supporting the existence of genetic heterogeneity in this neuropathy. In order to investigate the possibility of another disease locus on chromosome 1, we analyzed this family further, using DNA polymorphisms of 6 genes. Absence of linkage makes a second disease locus on chromosome 1 unlikely.

Address correspondence and reprint requests to Dr. C. Van Broeckhoven, Department of Biochemistry, University of Antwerp, UIA, Universiteitsplein 1, B2610 Antwerpen, Belgium.

This work was partly financed by the Association Française centre lea Myopathies.

Received November 4, 1988. Accepted for publication in final form December 20, 1988.




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