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Continuous levodopa infusions to treat complex dystonia in Parkinson's disease

Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ.

We report the clinical spectrum of 3 patients with Parkinson's disease who experienced complex patterns of levodopa-related dystonia. Dystonia was unrelieved by multiple medication regimens but responded well to continuous, duodenal levodopa infusions. Patients were able to remain mobile without severe dystonia despite a very narrow window of benefit between the levodopa concentration necessary to achieve the "on" state and that which caused the onset of dystonic spasms.

Address correspondence and reprint requests to Dr. Sage, Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, CN 19, New Brunswick, NJ 08903.

Received October 11,1988. Accepted for publication in final form January 23,1989.

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