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Nerve regeneration patterns after acute ischemic injury

James A. Haley Veterans' Hospital and University of South Florida College of Medicine, Tampa, FL
The Institute for Basic Research in Developmental Disabilities, Staten Island, NY
Albert Einstein College of Medicine, Bronx, NY.

We performed morphologic studies on regeneration of the cat's hind limb nerves, following simultaneous ligation of the aorta and right femoral artery. There were 2 regeneration patterns depending on the extent of ischemic necrosis. When nerve infarcts were limited only to intrafascicular regions, there was no basic change of nerve microarchitecture during regeneration. Extension of the necrosis to the perineurium resulted in replacement of the original fascicle by a collection of small fascicles, many of which were surrounded by their own perineurium. These mini fascicles formed within the boundaries of the old perineurium.

Address correspondence and reprint requests to Dr. Korthals, Department of Neurology, USF College of Medicine, 12901 Bruce B. Downs Blvd., Box 55, Tampa, FL 33612.

Supported by VA Medical Research Funds.

Received October 31,1988. Accepted for publication in final form February 2,1989.

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