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NEUROLOGY 1989;39:1031
© 1989 American Academy of Neurology

Spinal epidural lipomatosis

A serious complication of iatrogenic Cushing's syndrome

J. G. Kaplan, MD, E. Barasch, MD, A. Hirschfeld, MD, L. Ross, MD, K. Einberg, MD and M. Gordon, MD

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY (Drs. Kaplan, Einberg, and Gordon)
Department of Radiology, Albert Einstein College of Medicine, Bronx, NY (Dr. Barasch)
Department of Neurosurgery, Albert Einstein College of Medicine, Bronx, NY (Dr. Hirschfeld)
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (Dr. Ross), Albert Einstein College of Medicine, Bronx, NY.

Our experience and review of the literature demonstrate that spinal epidural lipomatosis is a rare but serious neurologic complication of iatrogenic Cushing's syndrome. Most patients develop slowly progressive paraparesis over months, but a subgroup exists which presents with acute, irreversible paraplegia. We consider therapeutic options.

Address correspondence and reprint requests to Dr. Kaplan, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

Received August 29, 1988. Accepted for publication in final form February 27, 1989.






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