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NEUROLOGY 1989;39:1066
© 1989 American Academy of Neurology

Autologous adrenal medullary transplant in progressive supranuclear palsy

William C. Koller, MD, PhD, Robert Morantz, MD, Bridget Vetere-Overfield, RN and Michael Waxman, MD

Department of Neurology, University of Kansas Medical Center, Kansas City, KS (Dr. Koller and Ms. Vetere-Overfield)
Department of Neurosurgery, Research Medical Center, Kansas City, MO (Dr. Morantz)
Department of Pulmonary Medicine, Research Medical Center, Kansas City, MO (Dr. Wazman).

We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy, using the method Madrazo has employed for neural transplantation in Parkinson's disease. Major and minor complications occurred post-operatively from which the patients recovered. One patient had a marked improvement in his postural stability and a decreased incidence of falling. This change was evident at 1 month after surgery and has remained for the 6 months of follow-up. Postural reflexes were not altered in the other 2 patients. There was no change in extraocular movements, speech, or the rigid-bradykinetic features of parkinsonism in any patient. Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy.

Address correspondence and reprint requests to Dr. Koller, Department of Neurology, University of Kansas Medical Center, 39th and Rainbow Blvd., Kansas City, KS 66103.

Received December 13, 1988. Accepted for publication in final form February 8, 1989.






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