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Gadolinium-DTPA-enhanced magnetic resonance imaging in intractable partial epilepsy

Departments of Neurology and Neuroradiology, Mayo Clinic, Rochester, MN.

We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26% the unenhanced image was positive, and the abnormality enhanced with Gd-DTPA. In 13% the unenhanced MR image was positive, but the abnormality did not enhance with Gd-DTPA. Gd-DTPA does not appear to increase the diagnostic yield of MRI in the presurgical evaluation of patients with partial epilepsy if the unenhanced MRIs are normal.

Address correspondence and reprint requests to Dr. Cascino, Department of Neurology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905.

Presented in part at the forty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received February 24, 1989. Accepted for publication in final form March 13, 1989.

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