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Agonist substitution in advanced Parkinson's disease

Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, IL.

We studied whether Parkinson's disease patients who had lost efficacy from pergolide (PERG) could benefit if transferred to bromocriptine (BCT) therapy. Using paired t-tests, we compared motor scores at baseline (when patients were still on PERG) and after 6 months of BCT therapy in 11 patients. No significant improvement occurred in any measure on BCT therapy (mean dose 33.6 mg/day), although patients remained stable. In 6 patients on whom "on/off" data were obtained, decreased "off" time and increased "on" time without chorea occurred, but these changes were not statistically significant. The side effect profile was similar with the 2 drugs.

Address correspondence and reprint requests to Dr. Goetz, Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, 1725 West Harrison Street, Chicago, IL 60612.

Supported by Sandoz Pharmaceuticals, the United Parkinson Foundation, and the Boothroyd Foundation.

Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.

Received January 26, 1989. Accepted for publication in final form February 28, 1989.

This article has been cited by other articles:

				C. G. Goetz, L. Blasucci, and G. T. Stebbins Switching dopamine agonists in advanced Parkinson's disease: Is rapid titration preferable to slow? Neurology, April 1, 1999; 52(6): 1227 - 1227. [Abstract] [Full Text] [PDF]